- Prof. Xiao-Jiang Li
- GHM Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong, China.
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Special Issue Introduction
Animal models are essential to the investigation of neurodegenerative diseases and the development of effective treatment. Genetically modified rodents have been widely used to model neurodegenerative diseases and provided important insights into disease pathogenesis. Recently developed gene-editing tool CRISPR-Cas9 also allowed the generation of large animal (rabbit, pig, monkey) models that can recapitulate important pathological features seen in the patient brains. This special issue will discuss the strengths and limitations of animal models of different species and provide an overview for using animal models to better understand the pathogenesis of neurodegenerative diseases and to develop effective therapies.
Potential author list
Han-Xiang Deng, Department of Neurology, Northwestern University, Chicago, IL, USA.
Huu Phuc Nguyen, Department of Human Genetics, Ruhr University of Bochum, Bochum, Germany.
Zhanjun Li, Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, Jilin, China.
Liangxue Lai, Southern China Institute of Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China.
Xiao-Jiang Li, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong, China.
Submission Deadline31 May 2022