- Prof. Zili You
School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
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- Prof. Yu Tang
Xiangya Hospital, Central South University, Changsha, Hunan, China.
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Special Issue Introduction
Glia cells, such as microglia and astrocytes, are the major population of cells in the central nervous system (CNS), which play an important role in mediating neuroinflammation and have been tightly associated with neuronal alteration or neurodegeneration. Glia cells routinely maintain the homeostasis of the CNS, by modulating neuronal excitability and viability, regulating neurogenesis and synaptogenesis, as well as sculpturing synaptic connectivity. However, neuroimmunology dysfunction could contribute to the pathogenesis of a variety of neurological diseases such as Parkinson’s disease, Alzheimer’s disease, Amyotrophic lateral sclerosis, and other neurological disorders. Ageing, as one of the most important risk factors for the pathogenesis of neurodegenerative diseases, could give rise to altered neuroinflammatory profiles and subdued functions of glia cells. Moreover, in recent years, with the advent of single-cell RNA-seq analysis, the role of glia cells has been demonstrated to be rather heterogeneous and context-dependent.
In this research topic, we will discuss the functions of multiple glia types in neurological/neurodegenerative diseases, linking glial dysfunctions with the combined variables such as ageing, neuropathological conditions, and disease stages. We also welcome the studies on glial (dys)functions by using high-throughput detection and bioinformatics analysis. Any type of manuscript, including original and review article that is related with neuroinflammation in neurological diseases, is encouraged to submit.
Submission Deadline30 Apr 2023