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Figure 2. Comparison of the structural polymorphism of amyloid fibrils formed by tau, α-syn, and TMEM106B. The topology diagrams show different polymorphic structures of brain-extracted tau fibrils (A), brain-extracted and in vitro assembled α-syn fibrils (B), and brain-extracted TMEM106B fibrils (C). AD: Alzheimer’s disease; ALS: amyotrophic lateral sclerosis; CBD: corticobasal degeneration; CTE: chronic traumatic encephalopathy; DLB: dementia with Lewy bodies; FTLD: frontotemporal lobar degeneration; MSA: multiple system atrophy; PD: Parkinson's disease; PDD: Parkinson's disease with dementia; PiD: Pick's disease; PSP: progressive supranuclear palsy.