fig6

Figure 6. Reduction of dopaminergic proteins in the striatum of G59S Tg and G71R Tg mice. (A, B) Western blots show the expression of DAT and TH in the striatum homogenates of 1- and 24-month-old nTg, WT Tg, G59S Tg, and G71R Tg mice. Actin was used as the loading control. The bar graph estimates the levels of DAT and TH expression normalized against β-actin (n = 4 per genotype). Data are presented as mean ± SEM. Two-way ANOVA with Sidak’s multiple comparisons test was used for statistical analysis. ^**P = 0.0054, ^****P < 0.0001. ns: Not significant.