fig2

Figure 2. (A) Schedule of MRI scans. Cannula implantation was carried out in Week -11. ICV administration began in Week 1. MR images were acquired in Weeks 1, 4, 9, 14, 19, 25, 31, 37, 43, and 49. MR images acquired in Week -1 were taken as the baseline. (B) Representative MR images show there was no significant brain atrophy in Week 49 when compared with the baseline (Week 11). (C-E) Kruskal-Wallis H test revealed no significant difference between different time points in the average total hippocampus volumes (P = 0.775), the average left hippocampus volumes (P = 0.770), and the average right hippocampus volumes (P = 0.606). Data are presented as mean ± standard deviation (SD). MRI: Magnetic resonance imaging; ICV: intracerebroventricular.