Hot Keywords
Ageing Neurodegenerative Diseases Neurodegeneration AD

Topic: Protein Phase Separation and Amyloid Aggregation in Neurodegenerative Diseases

A special issue of Ageing and Neurodegenerative Diseases

ISSN 2769-5301 (Online)

Submission deadline: 31 May 2023

Guest Editor(s)

  • Prof. Cong Liu
    Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, China.

    Website | E-mail

  • Prof. Jian Wang

    Department of Neurology, Huashan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.

    Website | E-mail

Special Issue Introduction

Protein liquid-liquid phase separation (LLPS) plays a crucial role in mediating dynamic assembly of different membraneless organelles such as stress granules and P-body. Dysregulation of protein LLPS leads to aberrant phase transition and protein amyloid aggregation which is closely associated with different neurodegenerative diseases (ND) including Alzheimer’s disease and Parkinson’s disease. This special issue will mainly focus on (1) discovery and characterization of new pathological amyloid protein in NDs; (2) mechanistic basis underlying protein LLPS and pathological aggregation in NDs; (3) different pathological activities of amyloid protein aggregates in disease; (4) developing different strategies for preventing pathological amyloid aggregation. Research articles, reviews, and comments are all welcomed.


Protein liquid-liquid phase separation (LLPS), pathological protein aggregation, amyloid, Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis

Submission Deadline

31 May 2023

Submission Information

For Author Instructions, please refer to
For Online Submission, please login at
Submission Deadline: 31 May 2023
Contacts: Leila Wang, Assistant Editor,

Published Articles

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