- Prof. Qian Yang
- Tangdu Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, China.
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Special Issue Introduction
The prevalence of neurodegenerative diseases is expected to rise due to the increased life expectancy and aging community in most countries, which imposes a considerable socioeconomic challenge. Neurodegenerative diseases result from the gradual and progressive loss of selective populations of neurons, leading to dysfunction of the nervous system. Considerable evidence indicates that factors including genetic mutations, protein misfolding, and oxidative stress act cumulatively over a lifetime to impact the vulnerability of an individual of developing neurodegeneration.
Currently, there is no cure for neurodegenerative diseases, and the treatments available only manage the symptoms. This is owing in part to the delayed diagnosis as the pathogenic process typically starts many years before the manifestation of clinical symptoms, and the conventional diagnostic methods do not provide characteristic features that allow the accurate diagnosis of this chronic neurodegenerative disorder.
To enable timely interventions, early and accurate diagnosis of neurodegenerative diseases in clinical practice is urgently needed. Approaches to early diagnosis based on molecular tools and neuroimaging methods are rapidly expanding and helpful in patients with first signs of neurodegenerative diseases. For instance, circulating exosomal miRNAs represent a new class of promising early noninvasive biomarkers for neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington disease, and amyotrophic lateral sclerosis.
The special issue will present a comprehensive overview of the latest advances in the field of early diagnosis for neurodegenerative diseases. The reviews cover clinical assessment, serum biomarkers, and functional neuroimaging for early diagnosis and discussion of the existing problems and future challenges.
Submission Deadline30 Jun 2022